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--- b74253ce-6228-11ee-9cb3-d4ae52ce2496 [2023/10/03 22:21] – [Conclusions] omnipedia
+++ b74253ce-6228-11ee-9cb3-d4ae52ce2496 [2023/12/30 17:35] (current) – [Causes] omnipedia
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 ====== Autoimmunity ======
-Autoimmune inflammatory reactions encompass a group of immune responses where the body's immune system mistakenly targets its own tissues, resulting in inflammation and potential tissue damage. This phenomenon arises from a breakdown in the immune system's ability to differentiate between self and non-self antigens.
+Autoimmune inflammatory reactions encompass a group of immune responses where the body's immune system mistakenly targets its own tissues, resulting in inflammation and potential tissue damage. This phenomenon arises from a breakdown in the immune system's ability to differentiate between self and non-self antigens. The incidence in quite high cosidering recent studies.
+[(General1>>
+title: Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK
+url: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00457-9/fulltext
+)]
 ===== Causes =====
 The underlying causes of autoimmune inflammatory reactions are complex. Genetic predispositions can make certain individuals more susceptible to autoimmune diseases. Additionally, environmental factors like infections, hormonal imbalances, and exposure to certain chemicals can trigger autoimmune responses. While autoimmune disorders have long been recognized, recent concerns have arisen regarding autoimmune reactions potentially linked to COVID-19 mRNA vaccines.
+[(Vax1>>
+title: New-onset autoimmune phenomena post-COVID-19 vaccination
+url: https://onlinelibrary.wiley.com/doi/10.1111/imm.13443
+)]
+[(Vax2>>
+title: COVID-19 Vaccination and the Rate of Immune and Autoimmune Adverse Events Following Immunization: Insights From a Narrative Literature Review
+url: https://www.frontiersin.org/articles/10.3389/fimmu.2022.872683/full
+)]
+[(Vax3>>
+title: Vaccinations and Autoimmune Diseases
+url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402446/
+)]
+[(Vax3bis>>
+title: Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues
+url: https://www.tandfonline.com/doi/full/10.1080/08916934.2023.2259123
+)]
+[(Vax4new>>
+title: Covid-19: Regulators warn that rare Guillain-Barré cases may link to J&J and AstraZeneca vaccines
+url: https://www.bmj.com/content/374/bmj.n1786/rr-0
+)]
+In general agents with immune-enhancing properties like infectious agents, silicone (breast implant), and aluminium salts (a common adjuvant), have been associated with immune-mediated diseases. Recently, conditions like siliconosis, Gulf War Syndrome, Macrophagic Myofasciitis Syndrome, and post-vaccination phenomena have been linked to prior exposure to these factors.
+[(Other4>>
+title: ASIA: Autoimmune/inflammatory syndrome induced by adjuvants
+url: https://www.sciencedirect.com/science/article/abs/pii/S0896841110000788?via%3Dihub
+)]
+[(Other5>>
+title: Acute polyarthritis after influenza A (H1N1) immunization
+url: https://www.sciencedirect.com/science/article/abs/pii/S1297319X11000224?via%3Dihub
+)]
+[(Other6>>
+title: Adjuvant Systems for vaccines: 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood
+url: https://www.sciencedirect.com/science/article/pii/S0264410X19310199
+)]
+[(Other7>>
+title: The value of Autoimmune Syndrome Induced by Adjuvant (ASIA) - Shedding light on orphan diseases in autoimmunity
+url: https://www.sciencedirect.com/science/article/abs/pii/S1568997218300570
+)]
+In the case of HPV vaccine, several studies say that there is little correlation,
+[(HPV2>>
+title: Human papillomavirus vaccination and risk of autoimmune diseases: A large cohort study of over 2million young girls in France
+url: https://pubmed.ncbi.nlm.nih.gov/28750853/
+)]
+but other studies demonstrate that there is relevant correlation, if data is analyzed properly and without bias.
+[(HPV5>>
+title: The epidemiological profile of ASIA syndrome after HPV vaccination: an evaluation based on the Vaccine Adverse Event Reporting Systems
+url: https://link.springer.com/article/10.1007/s12026-014-8567-3#Abs1
+)]
+[(HPV6>>
+title: Letter to the editor – HPV vaccine and autoimmunity Incidence of new-onset autoimmune disease in girls and women with pre-existing autoimmune disease after quadrivalent human papillomavirus vaccination: a cohort study
+url: https://pubmed.ncbi.nlm.nih.gov/27864851/
+)]
+A problem in several studies is that as control group are considered subjects that did take an other type of vaccine, instead of a real placebo.
+[(HPV1>>
+title: HPV vaccine and autoimmune diseases: systematic review and meta-analysis of the literature
+url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196376/
+)]
+In several cases there was strong time correlation, so there are ongoing lawsuits.
+[(HPV4>>
+title: Gardasil Postural Orthostatic Tachycardia Syndrome (Pots) Lawsuits
+url: https://justicecounts.com/dangerous-drug-lawsuits/gardasil-lawsuits/postural-orthostatic-tachycardia-syndrome-pots/
+)]
+[(HPV3>>
+title: Postural tachycardia syndrome following human papillomavirus vaccination
+url: https://onlinelibrary.wiley.com/doi/10.1111/ene.12272
+)]
 ===== Mechanism =====